The paper covers the principles of the accelerator mass spectrometry (AMS), development and history of AMS method, peculiarities of sample preparation and AMS application for dating of samples using radioisotope 14С, in the investigation of various environmental objects as well as medical and biological investigations with radioisotopes ap plication. The comparison of AMS with other analytical techniques is made.

1. Kutschera W. Progress in isotope analysis at ultra-trace level by AMS. International Journal of Mass Spectrometry, 242 (2005). P. 145–160.
https://doi.org/10.1016/j.ijms.2004.10.029
2. Kutschera W., Müller W. «Isotope language» of the Alpine Iceman investigated with AMS and MS. Nuclear Instruments and Methods B, 204 (2003). P. 705-719.
https://doi.org/10.1016/S0168-583X(03)00491-9
3. Purser K.H., Smick T.H., Purser R.K. A precision 14C accelerator mass spectrometer. Nuclear Instruments and Methods B, 52 (1990) . P. 263-268.
https://doi.org/10.1016/0168-583X(90)90418-T
4. Straume T. et al. Measuring fast neutrons in Hiroshima at distances relevant to atomic-bomb survivors. Nature. vol. 424 (2003). P. 539-542.
https://doi.org/10.1038/nature01815
5. Pierce D.A. et al. Studies of the mortality of atomic bomb survivors. Radiation Research. 146 (1996). P. 1-27.
https://doi.org/10.2307/3579391
6. Walner A. et al. 41Ca - a possible neutron specific biomarker in tooth enamel. Nuclear Instruments and Met hods B. 223-224 (2004). P. 759-764.
7. Rivkina E.M. i dr. Metan v vechnomerzlyh otlozhenijah severo-vostochnogo sektora Arktiki. Kriosfera Zemli. 2006. T. 10, no 3. P. 23-41 [in Russian].
8. Wild E.M. et al. 14C dating with the bomb peak: An application to forensic medicine. Nuclear Instruments and Methods B. 172 (2000). P. 944-950.
https://doi.org/10.1016/S0168-583X(00)00227-5
9. Buraglio N., 2000, Accelerator Mass Spectrometry of 129I and Its Applications in Natural Water Systems. Acta Universitatis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 570.53 pp.Uppsala, ISBN 91-554-4819-4.
10. Garner R.C. et al. Comparative biotransformation studies of MeIQx and PhIP in animal models and humans. Cancer Letters. 143 (1999). P. 161-165.
https://doi.org/10.1016/S0304-3835(99)00118-4
11. Freeman S.P.H.T. et al. The study of skeletal calcium metabolism with 41Ca and 45Ca. Nuclear Instruments and Methods B, 172 (2000). P. 930-933.
12. Turteltaub K.W. et al. Accelerator mass spectrometry in biomedical dosimetry: relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA. Proceedings of National Academy of Sciences of USA. 87 (1990). P. 5288-5292.
https://doi.org/10.1073/pnas.87.14.5288
13 Kautiainen A., Vogel J.S., Turteltaub K.W. Dose-dehendent binding of trichloroethylene to hepatic DNA and protein at low doses in mice, Chemico-Biological Inter. 106 (1997). P. 109-121.
https://doi.org/10.1016/S0009-2797(97)00061-6
14. Guo Zhiyce et al. Development of Accelerator Mass Spectrometry in China, Proceedings of the Second Asia Parhrle Accelerator Conference, Beijing, China. P. 2001.
15. Burri D.J., Clifford A.J. Caratenoid and retinoid methabolism: Insights from isotope research, Archives in Bio chemistry and Biophysics (2004) 430. P. 110-119.
https://doi.org/10.1016/j.abb.2004.04.028
16. Maden C. The potential of accelerator mass secondary ion mass spectrometry in environmental sciences, A dissertation submitted to the Swiss Federal Institute of Technology Zurich, 2003.
17. Hollrmeyer K., Altmeyer W., Heinzle E., Pitra C. Species identification of Oetzi's clothing with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry based on peptide pattern similarities of hair digests, Rapid Communications in Mass Spectrometry (2008) 22. P. 2751-2767.
https://doi.org/10.1002/rcm.3679